An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn
Elsevier

March 2013 (No. 1)

Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) expressions in the testes of mice during fetal development

Katsuhiko Warita a,b,* Tomoko Mitsuhashi b,c, Shiho Fukui c, Ken-ichi Ohta a, Shingo Suzuki a, Takanori Miki a, Yoshiki Takeuchi a, Toshifumi Yokoyama c, Hiroshi Kitagawa c, Teruo Sugawara d, Nobuhiko Hoshi c

a Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan;

b Department of Pathology, Division of Molecular Diagnostics, University of Pittsburgh School of Medicine, Pittsburgh, USA;

c Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe, Japan;

d Health Services Center, Otaru University of Commerce, Otaru, Japan

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Abstract
The expression patterns of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) in fetal Leydig cells were compared by using immunohistochemistry. While StAR immunoreactivity was detected during the first steps of testis differentiation, SBP expression was detected slightly later. The timing of SBP expression closely correlated with that of the testosterone surge, an event which is known to induce masculinization. Our results suggest that SBP plays an important role in male sexual development via interactions with StAR.

Reproductive Biology 2013 13 1: 92–95.

* Corresponding author at: Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan; E-mail address: warita@med.kagawa-u.ac.jp