December 2013 (No. 4)
Influence of lysophosphatidic acid on estradiol production and follicle stimulating hormone action in bovine granulosa cells
Dorota Boruszewska 1, Emilia Sinderewicz, Ilona Kowalczyk-Zieba 1, Dariusz Jan Skarzynski, Izabela Woclawek-Potocka *
Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
The objective of the study was to examine the effect of lysophosphatidic acid (LPA) on 17β-estradiol (E2) synthesis and follicle stimulating hormone (FSH) action in bovine granulosa cells. We found that granulosa cells in the bovine antral follicle, in addition to the uterus and the CL, are also the site of LPA synthesis and the target for LPA action in the bovine reproductive tract. Our findings suggest that LPA stimulates E2 synthesis, probably via increased expression of FSHR and 17β-HSD genes.
Reproductive Biology 2013 13 4: 344–347.
* Corresponding author: 10-748 Olsztyn, ul. Tuwima 10, Poland; E-mail address: firstname.lastname@example.org (I. Woclawek-Potocka).
1 DB and IK-Z were supported by the European Union within the European Social Fund (DrINNO3).