An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn
Elsevier

September 2013 (No. 3)

Within-laboratory and between-laboratory variability in the measurement of anti-müllerian hormone determined within an external quality assurance scheme

Emily Zuvela a,b,* Melanie Walls b, Phillip Matson c,d

a External Quality Assurance Schemes for Reproductive Medicine, PO Box 162, Northlands, WA 6905, Australia

b Fertility Specialists of Western Australia, Bethesda Hospital, 25 Queenslea Drive, Claremont, WA 6010, Australia

c Fertility North, Suite 213, Specialist Medical Centre, Joondalup Health Campus, Shenton Avenue, Joondalup, WA 6027, Australia

d Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia

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Abstract
Ten laboratories in an external quality assurance scheme used the same assay to measure anti-müllerian hormone concentration (Beckman Coulter Gen II) and received twenty serum samples distributed over a 15 month period. The mean bias for all results was only -0.089%, but there was large coefficient of repeatability of 38.8% (sample bias ranged from -37.9% to +54.7%). While each laboratory showed good reproducibility, there was a wide range of average values relative to the consensus value from -24.0% to +22.7%. This betweenlaboratory variability suggests clinicians should use the same laboratory to avoid problems with result interpretation.

Reproductive Biology 2013 13 3: 255–257.

* Corresponding author: External Quality Assurance Schemes for Reproductive Medicine, PO Box 162, Northlands, WA 6905, Australia; E-mail address: info@eqasrm.com.au (E. Zuvela).