September 2013 (No. 3)
Within-laboratory and between-laboratory variability in the measurement of anti-müllerian hormone determined within an external quality assurance scheme
Emily Zuvela a,b,* Melanie Walls b, Phillip Matson c,d
a External Quality Assurance Schemes for Reproductive Medicine, PO Box 162, Northlands, WA 6905, Australia
b Fertility Specialists of Western Australia, Bethesda Hospital, 25 Queenslea Drive, Claremont, WA 6010, Australia
c Fertility North, Suite 213, Specialist Medical Centre, Joondalup Health Campus, Shenton Avenue, Joondalup, WA 6027, Australia
d Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia
Ten laboratories in an external quality assurance scheme used the same assay to measure anti-müllerian hormone concentration (Beckman Coulter Gen II) and received twenty serum samples distributed over a 15 month period. The mean bias for all results was only -0.089%, but there was large coefficient of repeatability of 38.8% (sample bias ranged from -37.9% to +54.7%). While each laboratory showed good reproducibility, there was a wide range of average values relative to the consensus value from -24.0% to +22.7%. This betweenlaboratory variability suggests clinicians should use the same laboratory to avoid problems with result interpretation.
Reproductive Biology 2013 13 3: 255–257.
* Corresponding author: External Quality Assurance Schemes for Reproductive Medicine, PO Box 162, Northlands, WA 6905, Australia; E-mail address: firstname.lastname@example.org (E. Zuvela).