An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn
Elsevier

June 2014 (No. 2)

Inhibition of embryo implantation in mice through vaginal administration of a proprotein convertase 6 inhibitor

Huiting Ho a,b, Ying Li a, Guiying Nie a,b,*

a Prince Henry’s Institute of Medical Research, Clayton, Victoria 3168, Australia

b Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia

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Abstract

Uterine proprotein convertase 6 (PC6) plays a critical role in embryo implantation in both mice and women. It was hypothesized that inhibiting uterine PC6 could prevent pregnancy. Vaginal administration of a PC6 inhibitor presents the ideal route for local drug delivery. A peptide-based PC6 inhibitor, C-30k-PEG Poly R that was previously shown to have properties of increased vaginal absorption and penetration was tested for its contraceptive potential in mice following vaginal administration. The study demonstrated that this approach could inhibit embryo implantation in some mice (24% completely and 47% partially inhibited).

Reproductive Biology 2014 14 2: 155-159.

* Corresponding author at: Prince Henry’s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia. E-mail address: guiying.nie@princehenrys.org