September 2014 (No. 3)
Long-term adverse effects of cyclophosphamide on follicular growth and angiogenesis in mouse ovaries
Kenji Ezoe, Nana Murata, Akiko Yabuuchi *, Takashi Okuno, Tamotsu Kobayashi, Osamu Kato, Keiichi Kato *
Kato Ladies Clinic, 7-20-3 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
The adverse effects of the anti-cancer agent cyclophosphamide (CTX) on follicular growth and ovarian angiogenesis were investigated in mice. CTX treatment irreversibly induced a loss of follicles through apoptosis and decreased microvascularization of the corpora lutea and follicles in a dose-dependent manner. Our findings demonstrated that CTX adversely affected the ovaries indicating the need to support an awareness of fertility preservation before chemotherapy is initiated.
Reproductive Biology 2014 14 3: 238-242.
* Corresponding authors: E-mail addresses: firstname.lastname@example.org (A. Yabuuchi), email@example.com (K. Kato)