An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn
Elsevier

September 2014 (No. 3)

Long-term adverse effects of cyclophosphamide on follicular growth and angiogenesis in mouse ovaries

Kenji Ezoe, Nana Murata, Akiko Yabuuchi *, Takashi Okuno, Tamotsu Kobayashi, Osamu Kato, Keiichi Kato *

Kato Ladies Clinic, 7-20-3 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan

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Abstract

The adverse effects of the anti-cancer agent cyclophosphamide (CTX) on follicular growth and ovarian angiogenesis were investigated in mice. CTX treatment irreversibly induced a loss of follicles through apoptosis and decreased microvascularization of the corpora lutea and follicles in a dose-dependent manner. Our findings demonstrated that CTX adversely affected the ovaries indicating the need to support an awareness of fertility preservation before chemotherapy is initiated.

Reproductive Biology 2014 14  3: 238-242.

* Corresponding authors: E-mail addresses: a-yabuuchi@towako-kato.com (A. Yabuuchi), k-kato@towako.net (K. Kato)