An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn

September 2014 (No. 3)

Long-term adverse effects of cyclophosphamide on follicular growth and angiogenesis in mouse ovaries

Kenji Ezoe, Nana Murata, Akiko Yabuuchi *, Takashi Okuno, Tamotsu Kobayashi, Osamu Kato, Keiichi Kato *

Kato Ladies Clinic, 7-20-3 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan

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The adverse effects of the anti-cancer agent cyclophosphamide (CTX) on follicular growth and ovarian angiogenesis were investigated in mice. CTX treatment irreversibly induced a loss of follicles through apoptosis and decreased microvascularization of the corpora lutea and follicles in a dose-dependent manner. Our findings demonstrated that CTX adversely affected the ovaries indicating the need to support an awareness of fertility preservation before chemotherapy is initiated.

Reproductive Biology 2014 14  3: 238-242.

* Corresponding authors: E-mail addresses: (A. Yabuuchi), (K. Kato)