An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn

September 2014 (No. 3)

Loss of PP2A and PTEN immunoexpression coexists with survivin overexpression in adenomyosis

Hui Zhang a,1, Jing Liu b,1, Xingbo Zhao a, Boran Liang c, Zeqing Wena, Mingjiang Li a,*

a Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong 250021, People’s Republic of China

b Jinan Maternity and Child Care Hospital, 2 Xiaojingsan Road, Jinan, Shandong 250012, People’s Republic of China

c School of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250021, People’s Republic of China

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Phosphatase and tensin homolog (PTEN) and protein phosphatase type 2A (PP2A) are negative modulators of PI3K/AKT/survivin signaling. To evaluate immunoexpression of PTEN, PP2A and survivin in adenomyosis, ectopic lesions from 28 patients with adenomyosis and endometria from 30 controls without adenomyosis were employed in the study. The expression of PTEN, PP2A and survivin was examined with the use of immunohistochemis- try. We found a decreased expression of PP2A and PTEN in adenomyosis. The expression of PTEN showed great individual differences in adenomyosis, although expression of both PP2A and PTEN was lower in adenomyosis than in normal endometria. In contrast, the expression of survivin was higher in adenomyosis. Our results suggest the important role of the PI3K cascade in the pathogenesis and development of adenomyosis.

Reproductive Biology 2014 14 3: 200-205.

* Corresponding author: E-mail address: (M. Li)

1 These authors contributed equally to the paper