An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn
Elsevier

December 2014 (No. 4) Volume 14

Differential expression of genes linked to the leukemia inhibitor factor signaling pathway during the estrus cycle and early pregnancy in the porcine endometrium

Monika M. Kaczmarek a,b,*, Kamil Krawczynski a, Joanna Najmula a, Zaneta P. Reliszko a, Malgorzata Sikora a, Zdzislaw Gajewski b

a Laboratory of Molecular Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland

b Department for Large Animal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Nowoursynowska 100, 02-797 Warsaw, Poland

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Abstract

The objective of this study was to determine the expression profiles of leukemia inhibitory factor (LIF) and its receptor (LIFR), interleukin 6 receptor (IL6R), tumor protein p53 (TP53) and B-cell CLL/lymphoma 2 (BCL2) in the porcine endometrium on selected days of the estrous cycle and pregnancy. Time- and reproductive status (estrous cycle/pregnancy) -specific patterns of expression were identified for all investigated genes. The most pronounced changes were seen on Days 12 and 14 of pregnancy when maternal recognition of pregnancy and implantation, respectively, occurs in pigs.

Reproductive Biology, 2014 14 (4): 293-297.

* Corresponding author at: Laboratory of Molecular Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland. E-mail address: m.kaczmarek@pan.olsztyn.pl (M.M. Kaczmarek)