An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn
Elsevier

March 2015 (No. 1)

Luteal phase defect is associated with impaired VEGF mRNA expression in the secretory phase endometrium

Olga N. Sadekova a,1, Liudmila A. Nikitina a,1,2,*, Timur N. Rashidov b, Irina N. Voloschuk c, Larisa M. Samokhodskaya a, Elena M. Demidova b, Vsevolod A. Tkachuk a

a Department of Biochemistry, Faculty of Fundamental Medicine, Moscow University, Moscow, Russia

b V.F. Snegirev Obstetrics and Gynaecology Clinic, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

c Department of Pathological Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

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Abstract

Endometrial morphology and expression of vascular endothelial growth factor (VEGF) was examined in the endometria of women with history of recurrent miscarriage (RM group) and of fertile women without history of gynecological diseases (control group). Luteal phase defect (LPD) was diagnosed in 42% cases in the RM group vs. 13% in controls. Endometrial VEGF mRNA expression was lower in LPD endometria compared to mature endometria. In conclusion, LPD in non-pregnant endometrium is associated with angiogenic abnormalities and may cause pregnancy complications.

Reproductive Biology 2015, 15, 1; 65-68

* Corresponding author at: Department of Biochemistry, Faculty of Fundamental Medicine, Moscow State University, Lomonosovsky ave. 31-5, 117192 Moscow, Russia; e-mail address: lunikit@gmail.com (L.A. Nikitina).
1 These authors contributed equally to this work.
2 Present address: Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Harrachgasse 21/7, 8010, Austria.